Sunset at the State Highway 43 overpass. Interstate 90 is the primary route for thousands of trucks into and out of Winona for manufacturers such as Fastenal, Bay State, Peerless Chain, Fanatics and Hal Leonard, along with retailers like Walmart, Target, Menards and Hy-Vee. To the east, I-90 will take you to Boston. to the west to Seattle. Take I-90 to Albert Lea and hang a left on I-35, you can drive all way south to Loredo, Texas. To right to Duluth. Image: Kevin O’Reilly